HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 76132Generated: October 30, 2026
Sodium Iodide → 5-(5-Iodopyridin-2-yloxy)pyrimidine
https://huagongshe.com/reaction/76132
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Iodide | HCID 5238 | — |
| Reactant | 1,4-Dioxane | HCID 31275 | — |
| Reactant | N,N-Dimethylethylenediamine | HCID 66053 | — |
| Reactant | 5-(5-Bromopyridin-2-yloxy)pyrimidine | HCID 66611594 | — |
| Catalyst | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 5-(5-Iodopyridin-2-yloxy)pyrimidine | HCID 66634762 | — |
Reaction Steps
A mixture of 550 mg (2.18 mmol) 5-(5-bromopyridin-2-yloxy)pyrimidine and 2.5 mL 1,4-dioxane is charged with 42 mg (0.22 mmol) CuI, 650 mg (4.36 mmol) NaI and 50 μl (0.44 mmo) N,N-dimethylethylendiamine. The reaction mixture is stirred at 110° C. over night. The mixture is allowed to cool down to r.t. and diluted with EtOAc. The mixture is washed with 5% aq. ammonia solution and water. The organic layer is dried with Na2SO4 and the solvent is removed in vacuo to yield the desired product without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08835472B2 |
|---|
| Source dataset | uspto-grants-2014_09 |
|---|
| ORD ID | ord-4aa93c5a560c44e086cbff263d57e443 |
|---|
| Source note | uspto-grants-2014_09 |
|---|
