反应详情

温度

-5 °C

1.00 g (5.64 mmol) N-(1,1-dimethyl-2-phenyl-ethyl)-formamide (I34) is added to 8 mL DCM and cooled down to −5° C. Then 1.50 g (11.3 mmol) aluminium chloride is added by several portions, stirred for 5 min, before 0.9 g (5.64) bromine is added over a period of 1 min. Having finished the addition, the mixture is stirred for two more minutes at 0° C., poured onto ice water and extracted with DCM. The organic layer is dried with MgSO4 and the solvent is removed in vacuo.

1. additionis added over a period of 1 min
2. additionthe addition
3. additionpoured onto ice water
4. extractionextracted with DCM
5. dry with materialThe organic layer is dried with MgSO4
6. customthe solvent is removed in vacuo