反应详情

A mixture of 28.5 g (75.0 mmol) 2-amino-3-(4-iodophenyl)propanoate hydrochloride in 300 mL ethanol and 300 mL water is added to a mixture of 14.2 g (375 mmol) NaBH4 and 600 mL water (gas evolution!) and the resulting mixture is stirred at reflux for 2 h. The ethanol is evaporated in vacuo and the remaining aq. Phase is extracted with DCM (4×). The combined organic layers are dried with Na2SO4 and the solvent is removed in vacuo. The compound is used without further purification.

1. temperatureat reflux for 2 h
2. customThe ethanol is evaporated in vacuo
3. extractionthe remaining aq. Phase is extracted with DCM (4×)
4. dry with materialThe combined organic layers are dried with Na2SO4
5. customthe solvent is removed in vacuo
6. customThe compound is used without further purification