反应详情

0.53 ml (6.89 mmol) methyl chloroformate are added to a mixture of 1.50 g (5.75 mmol) 1-(4-iodophenyl)propane-2-amine and 1.16 ml pyridine (14.3 mmol) in 30 ml DCM at 0° C. and the reaction mixture is stirred for 1 h at constant temperature. Further DCM is added and the organic solution is consecutively washed with aq. HCl-solution (0.5 mol/l) and water, dried with MgSO4 and the solvent is removed under reduced pressure. The crude product is used without further purification.

1. washthe organic solution is consecutively washed with aq. HCl-solution (0.5 mol/l) and water
2. dry with materialdried with MgSO4
3. customthe solvent is removed under reduced pressure
4. customThe crude product is used without further purification