HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyridine → N-[2-(5-bromo-pyridin-2-yl)-ethyl]-acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | Acetic Anhydride | HCID 7918 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | 2-(5-Bromopyridin-2-yl)ethan-1-amine | HCID 53403687 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | N-[2-(5-bromo-pyridin-2-yl)-ethyl]-acetamide | HCID 66611273 | — |
Reaction Steps
A mixture of 200 mg (1.00 mmol) 2-(5-bromopyridin-2-yl)ethanamine, 86.6 μL (1.09 mmol) pyridine and 2 mL DCM is charged with 103 μL (1.09 mmol) acetic anhydride and stirred at r.t. over night. The mixture is treated with saturated aq. NaHCO3 solution and extracted with DCM. The organic layer is dried with Na2SO4 and the solvent is evaporated in vacuo.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08835472B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-e8601ea0d2484d9cad20b61ed85036cf |
| Source note | uspto-grants-2014_09 |