反应详情

To 2.20 g (7.30 mmol) N-(4-((tert-butyldimethylsilyl)ethynyl)phenethyl)acetamide (I56.1) in 30 mL DCM are added 2.24 g (8.03 mmol) TBAF*H2O and the mixture is stirred at r.t. over night. The mixture is washed with water (2×). The organic layer is dried with Na2SO4 and the solvent is removed in vacuo. The crude product is purified by column chromatography (silica gel, DCM/MeOH 10/0→20/1).

1. washThe mixture is washed with water (2×)
2. dry with materialThe organic layer is dried with Na2SO4
3. customthe solvent is removed in vacuo
4. customThe crude product is purified by column chromatography (silica gel, DCM/MeOH 10/0→20/1)