HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 76172Generated: October 25, 2026
Hydrochloric Acid → 1-(4-((4-Ethoxyphenyl)ethynyl)phenyl)propan-2-amine hydrochloride
https://huagongshe.com/reaction/76172
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Tert-butyl 1-(4-((4-ethoxyphenyl)ethynyl)phenyl)propan-2-yl-carbamate | HCID 66611490 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 1-(4-((4-Ethoxyphenyl)ethynyl)phenyl)propan-2-amine hydrochloride | HCID 66610681 | — |
Reaction Steps
To 3.30 g (8.70 mmol) tert-butyl 1-(4-((4-ethoxyphenyl)ethynyl)phenyl)propan-2-yl-carbamate (I60) in 40 mL MeOH are added 20 mL (25 mmol) HCl (1.25M in MeOH). The mixture is stirred at 70° C. for 7 h. The solvent is removed in vacuo and the crude product is triturated with DIPE and dried in normal atmosphere.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08835472B2 |
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| Source dataset | uspto-grants-2014_09 |
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| ORD ID | ord-9977905a0b844ee4aae5f5837004ce90 |
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| Source note | uspto-grants-2014_09 |
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