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HRID76183

反应详情

EQUATION

反应方程式

HRID 76183 的结构方程式

REACTANTS

反应物

3
结构：O
HCID962

Water

H2O

结构：C#Cc1ccc(Cl)cc1
HCID70118

Benzene, 1-chloro-4-ethynyl-

C8H5Cl

结构：CC(=O)NC(C)Cc1ccc(I)cc1
HCID66611344

未命名化合物

PRODUCTS

生成物

1
结构：CC(=O)NC(C)Cc1ccc(C#Cc2ccc(Cl)cc2)cc1
HCID56924958

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

2
结构：Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1
催化剂HCID178418476

未命名化合物

结构：CCC(C)N
溶剂HCID24874

2-Butanamine

C4H11N

PROCEDURE

实验过程

To 45.5 mg (0.15 mmol) N-(1-(4-iodophenyl)propan-2-yl)acetamide (I52.1) and 27.3 mg (0.20 mmol) 1-chloro-4-ethynylbenzene in 750 μl sec-butylamine are added 14.3 (0.02 mmol) bis(triphenyphosphine)dichloropalladium (in 400 μl sec-butylamine) followed by 1.0 mL water. The reaction mixture is stirred at r.t. overnight. The solvent is removed in vacuo and the residue is purified by HPLC (ACN/H2O/TFA).

WORKUP

后处理

  1. customThe solvent is removed in vacuo
  2. customthe residue is purified by HPLC (ACN/H2O/TFA)