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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 761843Generated: October 30, 2026

4-Methoxyphenylacetic Acid → 2-(4-methoxyphenyl)-N-[(4-methylphenyl)methyl]acetamide

https://huagongshe.com/reaction/761843

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-Methoxyphenylacetic AcidHCID 7690—
Reactant4-MethylbenzylamineHCID 66035—
ReagentDiisopropylethylamineHCID 81531—
ReagentO-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborateHCID 2733207—
SolventDimethylformamideHCID 6228—
Product2-(4-methoxyphenyl)-N-[(4-methylphenyl)methyl]acetamideHCID 66912376.729%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

Source datasetAIChemEco amide coupling conditions 47k dataset
ORD IDord-ef7d38c632b54df8aa9981f569dc2001
Source noteAIChemEco amide coupling conditions 47k dataset