HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylcarbamoyl Chloride → 3-(1-(4-((4-Ethoxyphenyl)ethynyl)phenyl)ethyl)-1,1-dimethylurea
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylcarbamoyl Chloride | HCID 6598 | — |
| Reactant | 1-(4-((4-Ethoxyphenyl)ethynyl)phenyl)ethanamine | HCID 66610326 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 3-(1-(4-((4-Ethoxyphenyl)ethynyl)phenyl)ethyl)-1,1-dimethylurea | HCID 56924990 | — |
Reaction Steps
To 26.5 mg (0.10 mmol) 1-(4-((4-ethoxyphenyl)ethynyl)phenyl)ethanamine (I63) and 27.7 μL (0.20 mmol) TEA in 1.5 mL DCM are added 11.0 μl (0.12 mmol) dimethylcarbamyl chloride at 0° C. The reaction mixture is stirred at r.t. over night and directly purified by HPLC (MeOH/H2O/NH3).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08835472B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-0343594e86c4472581e234896a7c6929 |
| Source note | uspto-grants-2014_09 |