HuagongsheHuagongshe Chemistry Print Report · For research reference only
Piperidine → N-(1-(4-((4-(piperidine-1-carbonyl)phenyl)ethynyl)phenyl)propan-2-yl)acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Piperidine | HCID 8082 | — |
| Reactant | O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733207 | — |
| Reactant | 4-((4-(2-Acetamidopropyl)phenyl)ethynyl)benzoic acid | HCID 66610590 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | N-(1-(4-((4-(piperidine-1-carbonyl)phenyl)ethynyl)phenyl)propan-2-yl)acetamide | HCID 66611192 | — |
Reaction Steps
To 30 mg (0.10 mmol) 4-((4-(2-acetamidopropyl)phenyl)ethynyl)benzoic acid (I72.2) in 1 mL DMF are added 20.0 μl (0.10 mmol) TEA and 50 mg (0.15 mmol) TBTU. The mixture is stirred at r.t. for 5 min before it is added to 10 mg (0.12 mmol) piperidine in 500 μl DMF. After stirring at r.t. for 72 h the mixture is purified by HPLC (MeOH/H2O/NH3).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08835472B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-15e7a52d0df64fe2b41a392976651de6 |
| Source note | uspto-grants-2014_09 |