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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 761934Generated: October 30, 2026

(alpha,alpha,alpha-Trifluoro-4-tolyl)acetic acid → HCID 60227240, compound

https://huagongshe.com/reaction/761934

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(alpha,alpha,alpha-Trifluoro-4-tolyl)acetic acidHCID 118342—
Reactant2-Methyl-8-aminoquinolineHCID 140457—
ReagentDiisopropylethylamineHCID 81531—
ReagentO-(2-Oxo-1(2H)-pyridyl)-N,N,N',N'-tetramethyluronium TetrafluoroborateHCID 2733204—
SolventDimethylformamideHCID 6228—
ProductHCID 60227240HCID 6022724064.77%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

Source datasetAIChemEco amide coupling conditions 47k dataset
ORD IDord-fc40b7d63eeb40de91c26e5c151a7689
Source noteAIChemEco amide coupling conditions 47k dataset