反应详情

150 mg (1.03 mmol) 1-ethoxy-4-ethynylbenzene, 327 mg (1.08 mmol) N-(4-iodophen-ethyl)propionamide (I47.2) and 36 mg (0.05 mmol) bis(triphenylphosphine)dichloro-palladium in 2.0 mL water and 1.5 mL sec-butylamine are stirred at r.t. over night and for additional 4 h at 30° C. The reaction mixture is partitioned between DCM and water. The solvent of the organic layer is evaporated in vacuo and the residue is purified by HPLC (MeOH/H2O/NH3).

1. customThe reaction mixture is partitioned between DCM and water
2. customThe solvent of the organic layer is evaporated in vacuo
3. customthe residue is purified by HPLC (MeOH/H2O/NH3)