Water → 2-[4-(4-Fluorophenyl)oxan-4-yl]acetonitrile

Participants

Reaction Conditions

Reaction Steps

To a pre-dissolved solution of KOH (441 mg, 7.87 mmol) in ethylene glycol (20 ml) was added methyl 2-cyano-2-[4-(4-fluorophenyl)oxan-4-yl]acetate (1.09 g, 3.93 mmol). The mixture was heated to 120° C. for 3 h, and then cooled. H2O was added (50 ml), the product extracted with Et2O (3×50 ml), washed with H2O (50 ml), dried over NA2SO4, filtered and concentrated. Purified by normal phase SiO2 chromatography (5 to 40% EtOAc/hexanes) to give 2-[4-(4-fluorophenyl)oxan-4-yl]acetonitrile as a colorless oil (450 mg, 78%, m/z: 219.1 [M+H]+ observed).

Provenance & Evidence