HuagongsheHuagongshe Chemistry Print Report · For research reference only
[(3,4-Dimethoxyphenyl)methyl]({2-[4-(4-fluorophenyl)-2,2-dimethyloxan-4-yl]ethyl})amine → 2-[(9R)-9-(4-fluorophenyl)-6-oxaspiro[4.5]decan-9-yl]acetonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | [(3,4-Dimethoxyphenyl)methyl]({2-[4-(4-fluorophenyl)-2,2-dimethyloxan-4-yl]ethyl})amine | HCID 3735781 | — |
| Reactant | Methyl 2-cyano-2-[4-(4-fluorophenyl)-1-oxaspiro[5.5]undecan-4-yl]acetate | HCID 68313701 | — |
| Reactant | HCID 68314498 | HCID 68314498 | — |
| Reactant | 2-[4-(4-Fluorophenyl)-1-oxaspiro[5.5]undecan-4-yl]acetonitrile | HCID 68314512 | — |
| Product | 2-[(9R)-9-(4-fluorophenyl)-6-oxaspiro[4.5]decan-9-yl]acetonitrile | HCID 68314486 | — |
Reaction Steps
By the procedure described in the preparation of intermediate 10 substituting methyl 2-cyano-2-[4-(4-fluorophenyl)-1-oxaspiro[5.5]undecan-4-yl]acetate for methyl 2-cyano-2-[9-(4-fluorophenyl)-6-oxaspiro[4.5]decan-9-yl]acetate, 2-[4-(4-fluorophenyl)-1-oxaspiro[5.5]undecan-4-yl]acetonitrile was prepared (m/z 287.2 [M+H]+ observed).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08835488B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-e15cb1c8dddc45539463ba8a6eeb1b09 |
| Source note | uspto-grants-2014_09 |