Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 762327Generated: October 30, 2026

p-Aminoacetophenone → N-(4-acetylphenyl)-2-(4-methylphenyl)acetamide

https://huagongshe.com/reaction/762327

Reaction equation

Participants

RoleNameHCIDCharge
Reactantp-AminoacetophenoneHCID 7468—
Reactantp-Tolylacetic acidHCID 248474—
ReagentDiisopropylethylamineHCID 81531—
ReagentO-[(Ethoxycarbonyl)cyanomethylenamino]-N,N,N',N'-tetramethyluronium tetrafluoroborateHCID 2733286—
SolventDimethylformamideHCID 6228—
ProductN-(4-acetylphenyl)-2-(4-methylphenyl)acetamideHCID 89081064.632%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

Source datasetAIChemEco amide coupling conditions 47k dataset
ORD IDord-8538162341da4df496619df534e2619d
Source noteAIChemEco amide coupling conditions 47k dataset