Hydrochloric Acid → N-[3-(acetylmethylamino)-2-hydroxypropyl]-N-methylacetamide

Participants

Reaction Steps

To a solution of N-[3-(acetylmethylamino)-2-(tert-butyldimethyl silanyloxy)propyl]-N-methylacetamide (1.12 g, 3.54 mmol) in methanol (23 mL), hydrogen chloride 4M dioxane solution (0.357 mL, 1.426 mmol) was added dropwise at 0° C. and the reaction was stirred at r.t. overnight. Solvent was evaporated and the residue triturated with petroleum ether and decanted. The oil obtained after trituration was dried under vacuum affording N-[3-(acetylmethylamino)-2-hydroxypropyl]-N-methylacetamide (681 mg, 95% yield).

Provenance & Evidence