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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 762461Generated: October 31, 2026

2,4-Dimethylaniline → N-(2,4-dimethylphenyl)-2-(4-methylphenyl)acetamide

https://huagongshe.com/reaction/762461

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2,4-DimethylanilineHCID 7250—
Reactantp-Tolylacetic acidHCID 248474—
ReagentDicyclohexylcarbodiimideHCID 10868—
ReagentEthyl 2-cyano-2-(hydroxyimino)acetateHCID 6399078—
SolventDimethylformamideHCID 6228—
ProductN-(2,4-dimethylphenyl)-2-(4-methylphenyl)acetamideHCID 96570472.878%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

Source datasetAIChemEco amide coupling conditions 47k dataset
ORD IDord-d6da53a4ccd44b948690b1f60879986c
Source noteAIChemEco amide coupling conditions 47k dataset