反应详情

3-Noradamantane carboxylic acid (4.99 g, 30.1 mmol) and SOCl2 (5 mL, 69 mmol) in toluene (5 mL) were heated to 65° C. until vigorous evolution of gas commenced. The heating bath was removed for 5-10 minutes until gas evolution had moderated. Heating the reaction again at 65° C. was resumed for 2 hours. The reaction was cooled to room temperature, the volatiles removed in vacuo and toluene added and evaporated (2×) to remove excess SOCl2. The crude acid chloride was used without further purification.

1. customThe heating bath was removed for 5-10 minutes until gas evolution
2. temperatureHeating
3. customthe reaction again at 65° C.
4. customthe volatiles removed in vacuo and toluene
5. additionadded
6. customevaporated (2×)
7. customto remove excess SOCl2
8. customThe crude acid chloride was used without further purification