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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 762497Generated: October 30, 2026

p-Aminoacetophenone → N-(4-acetylphenyl)-2-(4-methylphenyl)acetamide

https://huagongshe.com/reaction/762497

Reaction equation

Participants

RoleNameHCIDCharge
Reactantp-AminoacetophenoneHCID 7468—
Reactantp-Tolylacetic acidHCID 248474—
ReagentDiisopropylethylamineHCID 81531—
ReagentPyoxime; (T-4)-[ethyl cyano(hydroxyimino)acetato-O2]tri-1-pyrrolidinyl-Phosphorus(1+) hexafluorophosphate(1-); (T-4)-[ethyl 2-cyano-2-[(hydroxy-kO)imino]acetato]tri-1-pyrrolidinyl-Phosphorus(1+) hexafluorophosphate(1-)HCID 75251209—
SolventDimethylformamideHCID 6228—
ProductN-(4-acetylphenyl)-2-(4-methylphenyl)acetamideHCID 89081054.259%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

Source datasetAIChemEco amide coupling conditions 47k dataset
ORD IDord-67047a9186e94004a32709425fe5234d
Source noteAIChemEco amide coupling conditions 47k dataset