反应详情

温度

65 °C

The product from Example 50D (300 mg, 0.97 mmol) in chloroform (20 mL) was treated with TMSI (389 mg, 1.95 mmol). The reaction mixture was stirred at 65° C. for 12 hrs, diluted with CH2Cl2, the organic was washed with H2O, dried over MgSO4, filtered and concentrated to afford the title compound. MS (DCI/NH4+) m/z 237 (M+H)+.

1. washthe organic was washed with H2O
2. dry with materialdried over MgSO4
3. filtrationfiltered
4. concentrationconcentrated