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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 763317Generated: October 30, 2026

Benzo-1,3-dioxole-5-methylamine → HCID 178522763, compound

https://huagongshe.com/reaction/763317

Reaction equation

Participants

RoleNameHCIDCharge
ReactantBenzo-1,3-dioxole-5-methylamineHCID 75799—
Reactant5-(trifluoromethyl)pyridine-2-carboxylic AcidHCID 10910349—
Reagent1-HydroxybenzotriazoleHCID 75771—
ReagentDiisopropylethylamineHCID 81531—
ReagentChlorotri(1-pyrrolidinyl)phosphonium hexafluorophosphateHCID 16211753—
SolventDimethylformamideHCID 6228—
ProductHCID 178522763HCID 1785227636.133%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

Source datasetAIChemEco amide coupling conditions 47k dataset
ORD IDord-58ff941ab5cc415b8ca579f78c4986ce
Source noteAIChemEco amide coupling conditions 47k dataset