HCID 178481629, compound → 5-Amino-3-methyl-imidazolidine-2,4-dione

Participants

Reaction Steps

To a solution of 5-benzylamino-3-methyl-imidazole-2,4-dione (Example 1.3, Part B) (400 mg, 1.84 mmol) in ethanol/ethyl acetate (50 mL, 1:1) was added 10% Pd/C catalyst (195 mg, 0.18 mmol). The flask was evacuated and filled with hydrogen three times and then stirred at room temperature for 23 h. After this period, the reaction mixture was filtered through celite and the filtrate was evaporated to give the product as a colourless solid (214 mg, 90%), mp 122-125° C. δH (300 MHz, CD3CN) 6.31 (br s, 1H, NH), 4.68 (d, J 1.5 Hz, 1H, CH), 2.87 (s, 3H, CH3). δH (300 MHz, D2O) 4.95 (s, 1H, CH), 2.96 (s, 3H, CH3). δC (75 MHz, D2O) 175.6, 158.5, 64.0 (CH), 24.3 (CH3).

Provenance & Evidence