Water → HCID 44226078, compound

HRID 76367Notes

Reaction equation

HRID 76367 reaction equation
[CH2:1]([N:3]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[N:6]=[C:5]([CH2:13][S:14][C:15]2[CH:20]=[CH:19][C:18]([CH3:21])=[CH:17][CH:16]=2)[C:4]1=[O:22])[CH3:2].[OH:23]OS([O-])=O.[K+].[OH2:29]>C1COCC1.O>[CH2:1]([N:3]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[N:6]=[C:5]([CH2:13][S:14]([C:15]2[CH:16]=[CH:17][C:18]([CH3:21])=[CH:19][CH:20]=2)(=[O:23])=[O:29])[C:4]1=[O:22])[CH3:2]

Participants

5

Reactant 3

HCID 962WaterHCID 23707502Potassium hydroxy sulfiteHCID 44226079HCID 44226079, compound

Product 1

HCID 44226078HCID 44226078, compoundYield 50%

Reagents, catalysts & solvents 1

HCID 21881883Oxolane--water (1/1)Solvent

Procedure

To 280 mg (0.90 mM) of 1-ethyl-3-{[(4-methylphenyl)thio]methyl}quinoxalin-2(1H)-one and 75.8 mg (0.90 mM) in a mixture of 6 ml of THF/water (50/50) were added portion wise 1.1 g (1.8 mM) of oxone. The reaction mixture was maintained under stirring for 30 min and water was added. A precipitate was filtrated and washed thoroughly with water, to give, after drying, 154 mg of 1-ethyl-3-{[(4-methylphenyl)sulfonyl]methyl}quinoxalin-2(1H)-one as a solid. Yield: 50%.

Workup

  1. temperatureThe reaction mixture was maintained
  2. filtrationA precipitate was filtrated
  3. washwashed thoroughly with water
  4. customto give
  5. customafter drying

Sources & evidence

ORD record
ord-05c850be5fb64d25bd4575dbf4fdb30b
Source dataset
uspto-grants-2014_09
Patent number
US08835634B2

Reaction notes

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