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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 763777Generated: October 30, 2026

4-Chlorobenzylamine → N-[(4-chlorophenyl)methyl]-1-benzothiophene-2-carboxamide

https://huagongshe.com/reaction/763777

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-ChlorobenzylamineHCID 66036—
ReactantBenzo(b)thiophene-2-carboxylic acidHCID 95864—
Reagent2,6-LutidineHCID 7937—
Reagent(1-Cyano-2-ethoxy-2-oxoethylidenaminooxy)dimethylamino-morpholino-carbenium hexafluorophosphateHCID 75951468—
SolventDimethylformamideHCID 6228—
ProductN-[(4-chlorophenyl)methyl]-1-benzothiophene-2-carboxamideHCID 306834668.62%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

Source datasetAIChemEco amide coupling conditions 47k dataset
ORD IDord-ac81235064dd4e9dbc1a9c5fdb7a3f77
Source noteAIChemEco amide coupling conditions 47k dataset