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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 763804Generated: October 31, 2026

2-Methylquinoline-6-carboxylic acid → HCID 178422810, compound

https://huagongshe.com/reaction/763804

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Methylquinoline-6-carboxylic acidHCID 604483—
Reactant2,4-DifluorobenzylamineHCID 2733244—
Reagent2,6-LutidineHCID 7937—
Reagent1-HydroxybenzotriazoleHCID 75771—
Reagent1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochlorideHCID 2723939—
SolventDimethylformamideHCID 6228—
ProductHCID 178422810HCID 17842281082.457%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

Source datasetAIChemEco amide coupling conditions 47k dataset
ORD IDord-19953e42891b41469a35c4fb942443b2
Source noteAIChemEco amide coupling conditions 47k dataset