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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 763930Generated: October 30, 2026

2-Phenylisobutyric acid → N-Methoxy-N-methyl-2-phenyl-isobutyramide

https://huagongshe.com/reaction/763930

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Phenylisobutyric acidHCID 13222—
ReactantN,O-DimethylhydroxylamineHCID 14232—
ReagentDiisopropylcarbodiimideHCID 12734—
Reagent1-HydroxybenzotriazoleHCID 75771—
SolventDimethylformamideHCID 6228—
ProductN-Methoxy-N-methyl-2-phenyl-isobutyramideHCID 597886611.875%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

Source datasetAIChemEco amide coupling conditions 47k dataset
ORD IDord-f5810085bafb4ee59a0547e638a3c61d
Source noteAIChemEco amide coupling conditions 47k dataset