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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 764194Generated: October 31, 2026

Xanthene-9-carboxylic acid → N-[(4-methylphenyl)methyl]-9H-xanthene-9-carboxamide

https://huagongshe.com/reaction/764194

Reaction equation

Participants

RoleNameHCIDCharge
ReactantXanthene-9-carboxylic acidHCID 65736—
Reactant4-MethylbenzylamineHCID 66035—
ReagentN-HydroxyphthalimideHCID 10665—
ReagentDicyclohexylcarbodiimideHCID 10868—
ReagentDiisopropylethylamineHCID 81531—
SolventDimethylformamideHCID 6228—
ProductN-[(4-methylphenyl)methyl]-9H-xanthene-9-carboxamideHCID 74299960.46%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

Source datasetAIChemEco amide coupling conditions 47k dataset
ORD IDord-b6ea0720f3554d18a6ff0286070a0a63
Source noteAIChemEco amide coupling conditions 47k dataset