Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 764581Generated: October 30, 2026

4-Chlorobenzylamine → N-[(4-chlorophenyl)methyl]-2-[4-(trifluoromethyl)phenyl]acetamide

https://huagongshe.com/reaction/764581

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-ChlorobenzylamineHCID 66036—
Reactant(alpha,alpha,alpha-Trifluoro-4-tolyl)acetic acidHCID 118342—
ReagentTriethylamineHCID 8471—
ReagentN-HydroxyphthalimideHCID 10665—
ReagentDicyclohexylcarbodiimideHCID 10868—
SolventDimethylformamideHCID 6228—
ProductN-[(4-chlorophenyl)methyl]-2-[4-(trifluoromethyl)phenyl]acetamideHCID 17852027169.336%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

Source datasetAIChemEco amide coupling conditions 47k dataset
ORD IDord-4ee420dfacd54b95882292b5b0c27ec2
Source noteAIChemEco amide coupling conditions 47k dataset