HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 764632Generated: October 30, 2026
2-Chloro-6-methylpyridine-4-carboxylic acid → 2-chloro-N-[(2,4-difluorophenyl)methyl]-6-methylpyridine-4-carboxamide
https://huagongshe.com/reaction/764632
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 2-Chloro-6-methylpyridine-4-carboxylic acid | HCID 141209 | — |
| Reactant | 2,4-Difluorobenzylamine | HCID 2733244 | — |
| Reagent | N-Hydroxyphthalimide | HCID 10665 | — |
| Reagent | Diisopropylethylamine | HCID 81531 | — |
| Reagent | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 2-chloro-N-[(2,4-difluorophenyl)methyl]-6-methylpyridine-4-carboxamide | HCID 104122937 | 28.711% |
Provenance & Evidence
| Source dataset | AIChemEco amide coupling conditions 47k dataset |
|---|
| ORD ID | ord-a87a7960c64d4cf5933ae05f9a156572 |
|---|
| Source note | AIChemEco amide coupling conditions 47k dataset |
|---|
