HuagongsheHuagongshe Chemistry Print Report · For research reference only
Oxalyl chloride → 2-Phenoxypyrimidine-4-carbonyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Oxalyl chloride | HCID 65578 | — |
| Reactant | 2-Phenoxy-pyrimidine-4-carboxylic acid | HCID 21992202 | — |
| Catalyst | Dimethylformamide | HCID 6228 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 2-Phenoxypyrimidine-4-carbonyl chloride | HCID 12970158 | — |
Reaction Steps
To a solution of 2-phenoxy-pyrimidine-4-carboxylic acid, 17, (0.19 g, 0.89 mmol) in methylene chloride (10 mL) containing a few drops of DMF is added oxalyl chloride (0.1 mL). The solution is stirred for 2 hours at room temperature and concentrated in vacuo to afford the desired product which is used without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07087615B2 |
| Source dataset | uspto-grants-2006_08 |
| ORD ID | ord-8b5716b643fe46a79cfea718435d5ecd |
| Source note | uspto-grants-2006_08 |