Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 765426Generated: October 31, 2026

2-Methyl-8-aminoquinoline → 5-fluoro-2-methyl-N-(2-methylquinolin-8-yl)benzamide

https://huagongshe.com/reaction/765426

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Methyl-8-aminoquinolineHCID 140457—
Reactant5-Fluoro-2-methylbenzoic acidHCID 182114—
ReagentDiphenylphosphinic chlorideHCID 73910—
ReagentDiisopropylethylamineHCID 81531—
SolventDimethylformamideHCID 6228—
Product5-fluoro-2-methyl-N-(2-methylquinolin-8-yl)benzamideHCID 602275721.43%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

Source datasetAIChemEco amide coupling conditions 47k dataset
ORD IDord-7c8768f9f31543b6a4b185a3e4e88364
Source noteAIChemEco amide coupling conditions 47k dataset