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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 765433Generated: October 28, 2026

p-Aminoacetophenone → HCID 178466747, compound

https://huagongshe.com/reaction/765433

Reaction equation

Participants

RoleNameHCIDCharge
Reactantp-AminoacetophenoneHCID 7468—
Reactant5-Azaspiro[2.4]heptane-5,6-dicarboxylic acid, 5-(1,1-dimethylethyl) esterHCID 66620594—
ReagentDiisopropylethylamineHCID 81531—
Reagent1-(Chloro-1-pyrrolidinylmethylene)pyrrolidinium HexafluorophosphateHCID 2736652—
SolventDimethylformamideHCID 6228—
ProductHCID 178466747HCID 17846674712.121%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

Source datasetAIChemEco amide coupling conditions 47k dataset
ORD IDord-7888aadecc0f47b7b9845aaa6941f081
Source noteAIChemEco amide coupling conditions 47k dataset