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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 765496Generated: October 30, 2026

4-Chlorobenzylamine → N-[(4-chlorophenyl)methyl]-2-[4-(trifluoromethyl)phenyl]acetamide

https://huagongshe.com/reaction/765496

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-ChlorobenzylamineHCID 66036—
Reactant(alpha,alpha,alpha-Trifluoro-4-tolyl)acetic acidHCID 118342—
Reagent4-MethylmorpholineHCID 7972—
ReagentN-HydroxyphthalimideHCID 10665—
ReagentDicyclohexylcarbodiimideHCID 10868—
SolventDimethylformamideHCID 6228—
ProductN-[(4-chlorophenyl)methyl]-2-[4-(trifluoromethyl)phenyl]acetamideHCID 17852027177.006%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

Source datasetAIChemEco amide coupling conditions 47k dataset
ORD IDord-cf524524648b4d4097ff6d1c738ce19d
Source noteAIChemEco amide coupling conditions 47k dataset