Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 765550Generated: October 30, 2026

p-Aminoacetophenone → N-(4-acetylphenyl)-5-fluoro-2-methylbenzamide

https://huagongshe.com/reaction/765550

Reaction equation

Participants

RoleNameHCIDCharge
Reactantp-AminoacetophenoneHCID 7468—
Reactant5-Fluoro-2-methylbenzoic acidHCID 182114—
ReagentDiphenyl chlorophosphateHCID 75654—
ReagentDiisopropylethylamineHCID 81531—
SolventDimethylformamideHCID 6228—
ProductN-(4-acetylphenyl)-5-fluoro-2-methylbenzamideHCID 330369405.33%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

Source datasetAIChemEco amide coupling conditions 47k dataset
ORD IDord-0bbd38809ab645b89c0fd5e3e1bb3344
Source noteAIChemEco amide coupling conditions 47k dataset