HuagongsheHuagongshe Chemistry Print Report · For research reference only
Allylamine → N2-allyl-5-bromo-N4-(3-hydroxyphenyl)-2,4-pyrimidinediamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Allylamine | HCID 7853 | — |
| Reactant | N4-(3,4-ethylenedioxyphenyl)-5-fluoro-N2-(3-hydroxyphenyl)-2,4-primidinediamine | HCID 22060334 | — |
| Reactant | HCID 22060529 | HCID 22060529 | — |
| Product | N2-allyl-5-bromo-N4-(3-hydroxyphenyl)-2,4-pyrimidinediamine | HCID 22061004 | — |
Reaction Steps
In a manner similar to the preparation of N4-(3,4-ethylenedioxyphenyl)-5-fluoro-N2-(3-hydroxyphenyl)-2,4-pyrimidinediamine, 5-bromo-2-chloro-N4-(3-hydroxyphenyl)-4-pyrimidineamine and allylamine were reacted to yield N2-allyl-5-bromo-N4-(3-hydroxyphenyl)-2,4-pyrimidinediamine. 1H NMR (CD3OD): δ 8.08 (s, 1H), 7.21 (t, 1H, J=8.1 Hz), 7.02-6.97 (m, 2H), 6.71 (dd, 1H, J=2.4 and 8.7 Hz), 5.91-5.77 (m, 1H), 5.19-5.09 (m, 2H), 3.94-3.89 (m, 2H); LCMS: ret. time: 18.33 min.; purity: 99%; MS (m/e): 322 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08835430B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-ef525292b20e44729ba9aa5917fbf024 |
| Source note | uspto-grants-2014_09 |