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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 76573Generated: October 25, 2026

6-Aminoindole → 5-fluoro-N4-(3-hydroxyphenyl)-N2-[(1H)-indol-6-yl]-2,4-pyrimidinediamine

https://huagongshe.com/reaction/76573

Reaction equation

Participants

RoleNameHCIDCharge
Reactant6-AminoindoleHCID 256096—
ReactantN4-(3,4-ethylenedioxyphenyl)-5-fluoro-N2-(3-hydroxyphenyl)-2,4-primidinediamineHCID 22060334—
Reactant2-chloro-5-fluoro-N-(3-hydroxyphenyl)-4-pyrimidineamineHCID 22060451—
Product5-fluoro-N4-(3-hydroxyphenyl)-N2-[(1H)-indol-6-yl]-2,4-pyrimidinediamineHCID 22060276—

Reaction Steps

In a manner similar to the preparation of N4-(3,4-ethylenedioxyphenyl)-5-fluoro-N2-(3-hydroxyphenyl)-2,4-pyrimidinediamine, 2-chloro-5-fluoro-N4-(3-hydroxyphenyl)-4-pyrimidineamine and 6-aminoindole were reacted to yield 5-fluoro-N4-(3-hydroxyphenyl)-N2-[(1H)-indol-6-yl]-2,4-pyrimidinediamine LCMS: ret. time: 18.13 min.; purity: 96%; MS (m/e): 336 (MH+).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08835430B2
Source datasetuspto-grants-2014_09
ORD IDord-67f9ed22e087447090cc71f70d94b4f1
Source noteuspto-grants-2014_09