3-(4-Aminophenoxy)-1,2-propanediol → HCID 22061139, compound

HRID 76632Notes

Reaction equation

HRID 76632 reaction equation
Cl[C:2]1[N:7]=[C:6]([NH:8][C:9]2[CH:14]=[CH:13][CH:12]=[C:11]([OH:15])[CH:10]=2)[C:5]([F:16])=[CH:4][N:3]=1.[OH:17][CH:18]([CH2:28][OH:29])[CH2:19][O:20][C:21]1[CH:27]=[CH:26][C:24]([NH2:25])=[CH:23][CH:22]=1>>[OH:17][CH:18]([CH2:28][OH:29])[CH2:19][O:20][C:21]1[CH:27]=[CH:26][C:24]([NH:25][C:2]2[N:7]=[C:6]([NH:8][C:9]3[CH:14]=[CH:13][CH:12]=[C:11]([OH:15])[CH:10]=3)[C:5]([F:16])=[CH:4][N:3]=2)=[CH:23][CH:22]=1

Participants

3

Reactant 2

HCID 4592603-(4-Aminophenoxy)-1,2-propanediolHCID 220604512-chloro-5-fluoro-N-(3-hydroxyphenyl)-4-pyrimidineamine

Product 1

HCID 22061139HCID 22061139, compound

Procedure

In like manner to the preparation of N4-(3,4-ethylenedioxyphenyl)-5-fluoro-N2-(3-hydroxyphenyl)-2,4-pyrimidinediamine, 2-chloro-5-fluoro-N-(3-hydroxyphenyl)-4-pyrimidineamine and 4-(2,3-dihydroxypropoxy)aniline were reacted to produce

Workup

  1. customwere reacted
  2. customto produce

Sources & evidence

ORD record
ord-a746898a668549918e563bbc7f75bea3
Source dataset
uspto-grants-2014_09
Patent number
US08835430B2

Reaction notes

Loading…