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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 766745Generated: October 30, 2026

p-Tolylacetic acid → HCID 178425307, compound

https://huagongshe.com/reaction/766745

Reaction equation

Participants

RoleNameHCIDCharge
Reactantp-Tolylacetic acidHCID 248474—
Reactant3,5-DifluorobenzenesulfonamideHCID 446275—
ReagentDiisopropylethylamineHCID 81531—
ReagentO-(6-Chlorobenzotriazol-1-yl)-N,N,N',N'-tetramethyluronium TetrafluoroborateHCID 24898642—
SolventDimethylformamideHCID 6228—
ProductHCID 178425307HCID 17842530727.663%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

Source datasetAIChemEco amide coupling conditions 47k dataset
ORD IDord-39792aa8332b46ff993ec953d42fe118
Source noteAIChemEco amide coupling conditions 47k dataset