huagongshe.com
HRID76699

反应详情

EQUATION

反应方程式

HRID 76699 的结构方程式

REACTANTS

反应物

2
结构：Oc1cccc(Nc2nc(Cl)ncc2F)c1
HCID22060451

未命名化合物

结构：Nc1cccc(-c2cc[nH]n2)c1
HCID178507526

未命名化合物

PRODUCTS

生成物

1
结构：Oc1cccc(Nc2nc(Nc3cccc(-c4cc[nH]n4)c3)ncc2F)c1
HCID178516085

未命名化合物

PROCEDURE

实验过程

In like manner to the preparation of N4-(3-chloro-4-trifluoromethoxyphenyl)-5-fluoro-N2-(3-hydroxyphenyl)-2,4-pyrimidineamine, the reaction of 2-chloro-5-fluoro-N4-(3-hydroxyphenyl)-4-pyrimidineamine with 3-(1H-pyrazol-3-yl)aniline gave 5-fluoro-N4-(3-hydroxyphenyl)-N2-[3-(1H-pyrazol-3-yl)phenyl]-2,4-pyrimidinediamine. LCMS: purity: 84%; MS 363 (MH+)

WORKUP

后处理

  1. customIn like manner to the preparation of N4-(3-chloro-4-trifluoromethoxyphenyl)-5-fluoro-N2-(3-hydroxyphenyl)-2,4-pyrimidineamine