HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methylamine hydrochloride → HCID 22060510, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methylamine hydrochloride | HCID 6364545 | — |
| Reactant | (+/-)-N2-(2,3-dihydro-2-methoxycarbonylbenzofuran-5-y1)-5-fluoro-N4-(3-trifluoromethoxyphenyl)-2,4-pyrimidinediamine | HCID 22060758 | — |
| Product | HCID 22060510 | HCID 22060510 | — |
Reaction Steps
In like manner to the preparation of (±)-N4-(3,4-difluorophenyl)-5-fluoro-N2-[2-(N-methylamino)carbonyl-2,3-dihydrobenzofuran-5-yl]-2,4-pyrimidinediamine, the reaction of methyl amine Hydrogen Chloride with (±)-N2-(2,3-dihydro-2-methoxycarbonylbenzofuran-5-yl)-5-fluoro-N4-(3-trifluoromethoxyphenyl)-2,4-pyrimidinediamine gave (±)-N2-[2,3-dihydro-(N-methylamino)carbonylbenzofuran-5-yl]-5-fluoro-N4-(3-trifluoromethoxyphenyl)-2,4-pyrimidinediamine LCMS: purity: 94%; MS (m/e): 464 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08835430B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-a6bd28cdc31c41e6b558323811cff6fa |
| Source note | uspto-grants-2014_09 |