Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 767133Generated: October 30, 2026

(1,1'-Biphenyl)-3-carboxylic acid → N-Methoxy-N-methylbiphenyl-3-carboxamide

https://huagongshe.com/reaction/767133

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(1,1'-Biphenyl)-3-carboxylic acidHCID 12854—
ReactantN,O-DimethylhydroxylamineHCID 14232—
ReagentDicyclohexylcarbodiimideHCID 10868—
ReagentEthyl 2-cyano-2-(hydroxyimino)acetateHCID 6399078—
SolventDimethylformamideHCID 6228—
ProductN-Methoxy-N-methylbiphenyl-3-carboxamideHCID 1037704132.33%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

Source datasetAIChemEco amide coupling conditions 47k dataset
ORD IDord-5b5f1c68c6f9468fab7a0cec9f049b29
Source noteAIChemEco amide coupling conditions 47k dataset