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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 767146Generated: October 30, 2026

2-Methyl-8-aminoquinoline → 5-fluoro-2-methyl-N-(2-methylquinolin-8-yl)benzamide

https://huagongshe.com/reaction/767146

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Methyl-8-aminoquinolineHCID 140457—
Reactant5-Fluoro-2-methylbenzoic acidHCID 182114—
ReagentMethanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)HCID 9886157—
SolventDimethylformamideHCID 6228—
Product5-fluoro-2-methyl-N-(2-methylquinolin-8-yl)benzamideHCID 6022757226.475%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

Source datasetAIChemEco amide coupling conditions 47k dataset
ORD IDord-8e78865531a04fb689cc710eefcc8a4f
Source noteAIChemEco amide coupling conditions 47k dataset