HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-Nitro-2H-pyrido[3,2-B][1,4]oxazin-3(4H)-one → 6-amino-2H,3H,4H-pyrido[3,2-b][1,4]oxazin-3-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-Nitro-2H-pyrido[3,2-B][1,4]oxazin-3(4H)-one | HCID 22060732 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Hydrochloric Acid | HCID 313 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 6-amino-2H,3H,4H-pyrido[3,2-b][1,4]oxazin-3-one | HCID 22060563 | — |
Reaction Steps
6-Nitro-2H-pyrido[3,2-b]-1,4-oxazin-3(4H)-one (1 g) was reduced under hydrogenolysis conditions using 10% Pd—C in methanol (50 mL) and 1N HCl solution (10 mL) at 50 psi for 2 h. The catalyst was filtered off and washed with methanol and 1N HCl solution. The filtrate was evaporated to give 6-amino-2H-pyrido[3,2-b]-1,4-oxazin-3(4H)-one.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08835430B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-c6ba821c952942a48978de2029937444 |
| Source note | uspto-grants-2014_09 |