HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 76777Generated: October 29, 2026
Thionyl Chloride → 1-(Benzyloxy)-4-(tert-butyl)-2-(chloromethyl)benzene
https://huagongshe.com/reaction/76777
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | (2-(Benzyloxy)-5-(tert-butyl)phenyl)methanol | HCID 59544156 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 1-(Benzyloxy)-4-(tert-butyl)-2-(chloromethyl)benzene | HCID 59544155 | — |
Reaction Steps
To a stirred solution of compound 4 (963 g, 3.56 mol) in anhydrous DCM (2000 mL) was added slowly SOCl2 (535 g, 4.5 mol) at 0° C. The mixture was stirred at 20° C. for 2 hours, then concentrated in vacuo to give compound 5 as an oil, which was used in the next reaction without further drying or purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08835639B2 |
|---|
| Source dataset | uspto-grants-2014_09 |
|---|
| ORD ID | ord-959544ec7cb143c48a8ef9cf375f0f66 |
|---|
| Source note | uspto-grants-2014_09 |
|---|
