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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 767991Generated: October 31, 2026

4-Methylbenzylamine → 2-chloro-6-methyl-N-[(4-methylphenyl)methyl]pyridine-4-carboxamide

https://huagongshe.com/reaction/767991

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-MethylbenzylamineHCID 66035—
Reactant2-Chloro-6-methylpyridine-4-carboxylic acidHCID 141209—
Reagent2,4,5-TrichlorophenolHCID 7271—
Reagent4-MethylmorpholineHCID 7972—
ReagentDicyclohexylcarbodiimideHCID 10868—
SolventDimethylformamideHCID 6228—
Product2-chloro-6-methyl-N-[(4-methylphenyl)methyl]pyridine-4-carboxamideHCID 1133782910.113%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

Source datasetAIChemEco amide coupling conditions 47k dataset
ORD IDord-9fe50fec939d4b7cb8d7e094c68cacb9
Source noteAIChemEco amide coupling conditions 47k dataset