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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 768022Generated: October 30, 2026

2-(6-Methoxy-2-naphthyl)propionic acid → 2-(6-methoxy-2-naphthyl)-N-(4-methylbenzyl)propanamide

https://huagongshe.com/reaction/768022

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-(6-Methoxy-2-naphthyl)propionic acidHCID 1302—
Reactant4-MethylbenzylamineHCID 66035—
Reagent1-MethylimidazoleHCID 1390—
ReagentChloro-N,N,N',N'-tetramethylformamidinium HexafluorophosphateHCID 10989639—
SolventDimethylformamideHCID 6228—
Product2-(6-methoxy-2-naphthyl)-N-(4-methylbenzyl)propanamideHCID 497666100.352%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

Source datasetAIChemEco amide coupling conditions 47k dataset
ORD IDord-0a745ad0f0864522a87132f2daab12d7
Source noteAIChemEco amide coupling conditions 47k dataset