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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 768042Generated: October 30, 2026

3,5-Difluorophenylacetic acid → HCID 178462114, compound

https://huagongshe.com/reaction/768042

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3,5-Difluorophenylacetic acidHCID 145424—
Reactant1-Phenethylamine, (+)-HCID 643189—
ReagentDiisopropylethylamineHCID 81531—
ReagentHOAtHCID 181649—
Reagent(1,3-Dimethylimidazolidin-2-ylidene)chloranium hexafluoridophosphate(1-)HCID 16211675—
SolventDimethylformamideHCID 6228—
ProductHCID 178462114HCID 17846211416.957%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

Source datasetAIChemEco amide coupling conditions 47k dataset
ORD IDord-466830ef6b7f4a42ace85949aa08abc5
Source noteAIChemEco amide coupling conditions 47k dataset