3,5-Dimethoxyphenol → 2-(3,5-Dihydroxyphenyl)-1-benzofuran-4,6-diol

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Reaction Steps

This compound was prepared using Method A from 3,5-dimethoxyphenol and 2-bromo-1-(3,5-dimethoxyphenyl)ethanone: Yield 74% following procedures A.2 and A.5; m.p. 244° C. (dec.); IR 3349, 2920, 1610, 1442, 1252, 1134 cm−1; 1H-NMR (500 MHz, δ ppm, DMSO-d6) 9.78 (s, 1H), 9.33 (s, 2H), 9.32 (s, 1H), 7.01 (s, 1H), 6.62 (d, J=2.0, 2H), 6.39 (s, 1H), 6.19-6.15 (m, 2H); 13C-NMR (126 MHz, δ ppm, CD3OD) 160.0, 158.6, 157.9, 154.5, 152.4, 134.1, 112.9, 103.9, 103.4, 99.8, 98.8, 90.8.

Provenance & Evidence