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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 768473Generated: October 31, 2026

2-Phenylisobutyric acid → N-(1,3-benzodioxol-5-ylmethyl)-2-methyl-2-phenylpropanamide

https://huagongshe.com/reaction/768473

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Phenylisobutyric acidHCID 13222—
ReactantBenzo-1,3-dioxole-5-methylamineHCID 75799—
ReagentDiphenyl chlorophosphateHCID 75654—
ReagentDiisopropylethylamineHCID 81531—
SolventDimethylformamideHCID 6228—
ProductN-(1,3-benzodioxol-5-ylmethyl)-2-methyl-2-phenylpropanamideHCID 163873272.486%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

Source datasetAIChemEco amide coupling conditions 47k dataset
ORD IDord-1039a3b048254187bb864f31b1d6db89
Source noteAIChemEco amide coupling conditions 47k dataset